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Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase catalytic subunit type 3' and Ligand = 'BDBM346191'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346191
PNG
(US10202373, Compound I-3 | US10202373, Example 3N)
Show SMILES CCc1ncc(-c2ccnc(NC(C)=O)c2)c2ccn(c12)S(C)(=O)=O
Show InChI InChI=1S/C17H18N4O3S/c1-4-15-17-13(6-8-21(17)25(3,23)24)14(10-19-15)12-5-7-18-16(9-12)20-11(2)22/h5-10H,4H2,1-3H3,(H,18,20,22)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a<10n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair