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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase catalytic subunit type 3' and Ligand = 'BDBM346228'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346228
PNG
(US10202373, Compound I-42 | US10202373, Example 10...)
Show SMILES CCOC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C19H20N4O4S/c1-3-27-19(24)22-17-10-13(6-8-20-17)16-11-21-12(2)18-15(16)7-9-23(18)28(25,26)14-4-5-14/h6-11,14H,3-5H2,1-2H3,(H,20,22,24)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a<10n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair