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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase regulatory subunit alpha' and Ligand = 'BDBM340451'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM340451
PNG
(US9758538, Example 141)
Show SMILES Nc1ncc(cn1)-c1cc(N[C@@]2(CO)CCCN(C2)C(=O)OCC(F)F)nc(n1)N1CCOCC1
Show InChI InChI=1S/C21H28F2N8O4/c22-16(23)11-35-20(33)31-3-1-2-21(12-31,13-32)29-17-8-15(14-9-25-18(24)26-10-14)27-19(28-17)30-4-6-34-7-5-30/h8-10,16,32H,1-7,11-13H2,(H2,24,25,26)(H,27,28,29)/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.0430n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
The biochemical assays of kinase activity of full-length PI3Kα (full-length p110α/p85α) or truncated PI3Kα (p110α/iSH2 p85&#...


US Patent US9758538 (2017)

More data for this
Ligand-Target Pair