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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase regulatory subunit beta' and Ligand = 'BDBM288970'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288970
PNG
(US10092563, Compound 107)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C21H22ClF3N10O/c1-11(29-17-12(9-26)16(27)31-20(28)32-17)18-30-14-4-2-3-13(22)15(14)19(36)35(18)34-7-5-33(6-8-34)10-21(23,24)25/h2-4,11H,5-8,10H2,1H3,(H5,27,28,29,31,32)/t11-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.20E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair