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Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM125326'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM125326
PNG
(US8772480, 149)
Show SMILES COc1ccc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)c2ccc(cc2)S(C)(=O)=O)cn1
Show InChI InChI=1/C24H25N7O3S/c1-14(16-5-8-19(9-6-16)35(4,32)33)17-11-20(23-28-15(2)29-24(25)31-23)22(27-12-17)30-18-7-10-21(34-3)26-13-18/h5-14H,1-4H3,(H,27,30)(H2,25,28,29,31)
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

US Patent
5n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...


US Patent US8772480 (2014)


BindingDB Entry DOI: 10.7270/Q2V123FJ
More data for this
Ligand-Target Pair