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Found 21 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform' and Ligand = 'BDBM246889'
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:In some embodiments, the PI3Kδ inhibitor is selective. By ¿selective¿ is meant that the compound binds to or inhibits a kinase with greater affi...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:Assay A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description: In some embodiments, the PI3Kδ inhibitor is selective. By ¿selective¿ is meant that the compound binds to or inhibits a kinase with greater aff...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:Assay A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were fir...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:Assay A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:Assay A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were fir...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:PI3Kα, PI3Kβ, PI3Kγ: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume o...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:The IC50s obtained by the method of Assay A at 1 mM ATP as described in the US Patent Publications.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:Assay A1 PI3Kδ: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibito...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:PI3Kα, PI3Kβ, PI3Kγ: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume o...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:Assay A1 PI3Kδ: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibito...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <100nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent