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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform' and Ligand = 'BDBM261180'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261180
PNG
(2-(4-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(N)=O)c1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C22H27ClN8O2/c1-5-33-20-15(13(4)30-22-19(12(3)24)21(26)27-10-28-22)6-16(23)11(2)18(20)14-7-29-31(8-14)9-17(25)32/h6-8,10,13,24H,5,9H2,1-4H3,(H2,25,32)(H3,26,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261180
PNG
(2-(4-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(N)=O)c1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C22H27ClN8O2/c1-5-33-20-15(13(4)30-22-19(12(3)24)21(26)27-10-28-22)6-16(23)11(2)18(20)14-7-29-31(8-14)9-17(25)32/h6-8,10,13,24H,5,9H2,1-4H3,(H2,25,32)(H3,26,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair