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Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform' and Ligand = 'BDBM334093'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334093
PNG
(8-[4-methoxy-3- (trifluoromethyl)phenyl]-9- methyl...)
Show SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2n(C)c(nc12)-c1ccc(OC)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3/c1-4-16(30)29-8-7-13(10-29)32-20-17-19(25-11-26-20)28(2)18(27-17)12-5-6-15(31-3)14(9-12)21(22,23)24/h5-6,9,11,13H,4,7-8,10H2,1-3H3/t13-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



Merck Sharp & Dohme

US Patent


Assay Description
The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4 Reactio...


US Patent US9730940 (2017)

More data for this
Ligand-Target Pair