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Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform' and Ligand = 'BDBM334127'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334127
PNG
(US9730940, Compound 3-62 | racemic-6-{[1- (cyclopr...)
Show SMILES CCn1c(nc2c(O[C@@H]3CN(CC3(C)C)C(=O)C3CC3)ncnc12)-c1cnc(C)nc1
Show InChI InChI=1S/C22H27N7O2/c1-5-29-18(15-8-23-13(2)24-9-15)27-17-19(29)25-12-26-20(17)31-16-10-28(11-22(16,3)4)21(30)14-6-7-14/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t16-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30n/an/an/an/an/an/a



Merck Sharp & Dohme

US Patent


Assay Description
The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4 Reactio...


US Patent US9730940 (2017)

More data for this
Ligand-Target Pair