BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM326253'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326253
PNG
(3-(1-(9H-purin-6-yl)pyrrolidin-2-yl)-7-fluoro-2-(p...)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C23H18FN7/c24-15-7-6-14-10-16(20(30-18(14)11-15)17-4-1-2-8-25-17)19-5-3-9-31(19)23-21-22(27-12-26-21)28-13-29-23/h1-2,4,6-8,10-13,19H,3,5,9H2,(H,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326253
PNG
(3-(1-(9H-purin-6-yl)pyrrolidin-2-yl)-7-fluoro-2-(p...)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C23H18FN7/c24-15-7-6-14-10-16(20(30-18(14)11-15)17-4-1-2-8-25-17)19-5-3-9-31(19)23-21-22(27-12-26-21)28-13-29-23/h1-2,4,6-8,10-13,19H,3,5,9H2,(H,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 521n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair