BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM326272'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326272
PNG
(US9637488, 38 | US9637488, 43)
Show SMILES Fc1ccc2cc(C3CCCCN3c3ncnc4[nH]cnc34)c(nc2c1)N1CCOCC1
Show InChI InChI=1S/C23H24FN7O/c24-16-5-4-15-11-17(22(29-18(15)12-16)30-7-9-32-10-8-30)19-3-1-2-6-31(19)23-20-21(26-13-25-20)27-14-28-23/h4-5,11-14,19H,1-3,6-10H2,(H,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326272
PNG
(US9637488, 38 | US9637488, 43)
Show SMILES Fc1ccc2cc(C3CCCCN3c3ncnc4[nH]cnc34)c(nc2c1)N1CCOCC1
Show InChI InChI=1S/C23H24FN7O/c24-16-5-4-15-11-17(22(29-18(15)12-16)30-7-9-32-10-8-30)19-3-1-2-6-31(19)23-20-21(26-13-25-20)27-14-28-23/h4-5,11-14,19H,1-3,6-10H2,(H,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair