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Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM326274'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326274
PNG
(US9637488, 42)
Show SMILES Nc1ncnc(N2CCCCC2c2cc3ccc(F)cc3nc2-c2ccccc2)c1C#N
Show InChI InChI=1S/C25H21FN6/c26-18-10-9-17-12-19(23(31-21(17)13-18)16-6-2-1-3-7-16)22-8-4-5-11-32(22)25-20(14-27)24(28)29-15-30-25/h1-3,6-7,9-10,12-13,15,22H,4-5,8,11H2,(H2,28,29,30)
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair