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Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM326281'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326281
PNG
(US9637488, 64)
Show SMILES Cc1cccc2cc([C@H]3CCCN3c3ncnc4nc[nH]c34)c(nc12)N1CCOCC1
Show InChI InChI=1S/C23H25N7O/c1-15-4-2-5-16-12-17(22(28-19(15)16)29-8-10-31-11-9-29)18-6-3-7-30(18)23-20-21(25-13-24-20)26-14-27-23/h2,4-5,12-14,18H,3,6-11H2,1H3,(H,24,25,26,27)/t18-/m1/s1
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair