Found 9 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase tankyrase-1' and Ligand = 'BDBM50188594' TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of TNKS1 (unknown origin) using biotin-NAD+ as substrate incubated for 1 hr in the presence of deoxy-oligonucleotide by ELISA analysis rel...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 7.5nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of TNKS-1 (unknown origin) using histone as substrate incubated for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of TNKS1 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 95.5nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...More data for this Ligand-Target Pair
