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Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily H member 2' and Ligand = 'BDBM315750'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM315750
PNG
(US10172859, Example 171 | US10172859, Example 178 ...)
Show SMILES OC(c1nccs1)c1cc(F)c(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1
Show InChI InChI=1S/C22H18F2N4O2S/c23-17-10-13(21(29)22-25-3-8-31-22)9-16(19(17)24)20-15-2-1-14(11-18(15)26-12-27-20)28-4-6-30-7-5-28/h1-3,8-12,21,29H,4-7H2
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PC cid
PC sid
UniChem
Article
US Patent
<1.00E+4n/an/an/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...


US Patent US10172859 (2019)


Article DOI: 10.1016/j.bmc.2008.10.070
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM315750
PNG
(US10172859, Example 171 | US10172859, Example 178 ...)
Show SMILES OC(c1nccs1)c1cc(F)c(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1
Show InChI InChI=1S/C22H18F2N4O2S/c23-17-10-13(21(29)22-25-3-8-31-22)9-16(19(17)24)20-15-2-1-14(11-18(15)26-12-27-20)28-4-6-30-7-5-28/h1-3,8-12,21,29H,4-7H2
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PC sid
UniChem
Article
US Patent
<1.00E+4n/an/an/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...


US Patent US10172859 (2019)


Article DOI: 10.1016/j.bmc.2008.10.070
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM315750
PNG
(US10172859, Example 171 | US10172859, Example 178 ...)
Show SMILES OC(c1nccs1)c1cc(F)c(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1
Show InChI InChI=1S/C22H18F2N4O2S/c23-17-10-13(21(29)22-25-3-8-31-22)9-16(19(17)24)20-15-2-1-14(11-18(15)26-12-27-20)28-4-6-30-7-5-28/h1-3,8-12,21,29H,4-7H2
PDB
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PC sid
UniChem
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US Patent
<1.00E+4n/an/an/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...


US Patent US9732094 (2017)


Article DOI: 10.1021/jm960871c
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM315750
PNG
(US10172859, Example 171 | US10172859, Example 178 ...)
Show SMILES OC(c1nccs1)c1cc(F)c(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1
Show InChI InChI=1S/C22H18F2N4O2S/c23-17-10-13(21(29)22-25-3-8-31-22)9-16(19(17)24)20-15-2-1-14(11-18(15)26-12-27-20)28-4-6-30-7-5-28/h1-3,8-12,21,29H,4-7H2
PDB
MMDB

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PC cid
PC sid
UniChem
Article
US Patent
<1.00E+4n/an/an/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...


US Patent US9732094 (2017)


Article DOI: 10.1021/jm960871c
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM315750
PNG
(US10172859, Example 171 | US10172859, Example 178 ...)
Show SMILES OC(c1nccs1)c1cc(F)c(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1
Show InChI InChI=1S/C22H18F2N4O2S/c23-17-10-13(21(29)22-25-3-8-31-22)9-16(19(17)24)20-15-2-1-14(11-18(15)26-12-27-20)28-4-6-30-7-5-28/h1-3,8-12,21,29H,4-7H2
PDB
MMDB

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PC cid
PC sid
UniChem
Article
US Patent
>2.50E+4n/an/an/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...


US Patent US9732094 (2017)


Article DOI: 10.1021/jm960871c
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM315750
PNG
(US10172859, Example 171 | US10172859, Example 178 ...)
Show SMILES OC(c1nccs1)c1cc(F)c(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1
Show InChI InChI=1S/C22H18F2N4O2S/c23-17-10-13(21(29)22-25-3-8-31-22)9-16(19(17)24)20-15-2-1-14(11-18(15)26-12-27-20)28-4-6-30-7-5-28/h1-3,8-12,21,29H,4-7H2
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
>2.50E+4n/an/an/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...


US Patent US10172859 (2019)


Article DOI: 10.1016/j.bmc.2008.10.070
More data for this
Ligand-Target Pair