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Found 2 Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM193020'
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193020(US9193726, 8)
Affinity DataIC50:  14.3nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193020(US9193726, 8)
Affinity DataEC50:  14nMAssay Description:Modulation of gamma-secretase in CHO cells expressing human APP assessed as reduction in amyloid beta (1 to 42 residues) production after 24 hrs by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed