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Found 3 Enz. Inhib. hit(s) with Target = 'Prostaglandin E2 receptor EP4 subtype' and Ligand = 'BDBM50308125'
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308125(4-[(1S)-1-({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thi...)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/molepH: 6.0 T: 2°CAssay Description:Transfected HEK 293(ebna) cells are maintained in culture, harvested and membranes are prepared by differential centrifugation, following lysis of th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308125(4-[(1S)-1-({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thi...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308125(4-[(1S)-1-({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thi...)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed