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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Protein arginine N-methyltransferase 5' and Ligand = 'BDBM297732'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297732
PNG
(US10118918, Compound 11 | US9732072, Compound 11 |...)
Show SMILES CC(C)(C)OC(=O)Nc1cccc(c1)C(=O)NCC(O)CN1Cc2ccccc2C1
Show InChI InChI=1S/C23H29N3O4/c1-23(2,3)30-22(29)25-19-10-6-9-16(11-19)21(28)24-12-20(27)15-26-13-17-7-4-5-8-18(17)14-26/h4-11,20,27H,12-15H2,1-3H3,(H,24,28)(H,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
General Materials.S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), bicine, KCl, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG)...


US Patent US9732072 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297732
PNG
(US10118918, Compound 11 | US9732072, Compound 11 |...)
Show SMILES CC(C)(C)OC(=O)Nc1cccc(c1)C(=O)NCC(O)CN1Cc2ccccc2C1
Show InChI InChI=1S/C23H29N3O4/c1-23(2,3)30-22(29)25-19-10-6-9-16(11-19)21(28)24-12-20(27)15-26-13-17-7-4-5-8-18(17)14-26/h4-11,20,27H,12-15H2,1-3H3,(H,24,28)(H,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair