BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Protein arginine N-methyltransferase 5' and Ligand = 'BDBM297750'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297750
PNG
(US10118918, Compound 29 | US9732072, Compound 29)
Show SMILES O[C@@H](CNC(=O)c1cc(NC2CCOCC2)ncn1)CN1Cc2ccccc2C1
Show InChI InChI=1S/C21H27N5O3/c27-18(13-26-11-15-3-1-2-4-16(15)12-26)10-22-21(28)19-9-20(24-14-23-19)25-17-5-7-29-8-6-17/h1-4,9,14,17-18,27H,5-8,10-13H2,(H,22,28)(H,23,24,25)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
General Materials.S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), bicine, KCl, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG)...


US Patent US9732072 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297750
PNG
(US10118918, Compound 29 | US9732072, Compound 29)
Show SMILES O[C@@H](CNC(=O)c1cc(NC2CCOCC2)ncn1)CN1Cc2ccccc2C1
Show InChI InChI=1S/C21H27N5O3/c27-18(13-26-11-15-3-1-2-4-16(15)12-26)10-22-21(28)19-9-20(24-14-23-19)25-17-5-7-29-8-6-17/h1-4,9,14,17-18,27H,5-8,10-13H2,(H,22,28)(H,23,24,25)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair