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Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein-serine O-palmitoleoyltransferase porcupine' and Ligand = 'BDBM50133869'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50133869
PNG
(CHEMBL3633800)
Show SMILES COc1cc(F)ccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C23H19FN4O3S3/c1-12-3-5-14-18(9-12)34-22(25-14)27-19(29)11-33-23-26-15-7-8-32-20(15)21(30)28(23)16-6-4-13(24)10-17(16)31-2/h3-6,9-10H,7-8,11H2,1-2H3,(H,25,27,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 27n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...


Bioorg Med Chem Lett 25: 5472-6 (2015)

More data for this
Ligand-Target Pair