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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RAF serine/threonine protein kinase' and Ligand = 'BDBM333646'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333646
PNG
(US9730937, Example 195 | ethyl 2-(3- tert-butyl-5-...)
Show SMILES CCOC(=O)Cn1nc(cc1NC(=O)Nc1cccc(Sc2ncnc3cc(OC)c(OC)cc23)c1)C(C)(C)C
Show InChI InChI=1S/C28H32N6O5S/c1-7-39-25(35)15-34-24(14-23(33-34)28(2,3)4)32-27(36)31-17-9-8-10-18(11-17)40-26-19-12-21(37-5)22(38-6)13-20(19)29-16-30-26/h8-14,16H,7,15H2,1-6H3,(H2,31,32,36)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/a>1.00E+3n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair