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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RET Kinase (V804M) (aa658-end)' and Ligand = 'BDBM284072'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM284072
PNG
(US10023570, Example 82 | US10174027, Example 82)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)[C@H](O)c2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H26N8O2/c1-34-18-24(17-32-34)22-13-25(27-23(14-30)16-33-37(27)19-22)21-7-8-26(31-15-21)35-9-11-36(12-10-35)29(39)28(38)20-5-3-2-4-6-20/h2-8,13,15-19,28,38H,9-12H2,1H3/t28-/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13.2n/an/an/an/a7.4n/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)

More data for this
Ligand-Target Pair