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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Receptor-interacting protein 1 (RIPK1)' and Ligand = 'BDBM50229510'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229510
PNG
(CHEMBL4073564)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C(C)(C)CO
Show InChI InChI=1S/C13H16F3NO2/c1-13(2,7-18)12(19)17(3)6-8-4-9(14)5-10(15)11(8)16/h4-5,18H,6-7H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>3.00E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair