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Found 10 Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 1' and Ligand = 'BDBM322158'
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataKi:  10nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataKi:  10nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataKi:  10nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataKi:  10nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataIC50:  300nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataIC50:  300nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataIC50:  330nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataIC50:  330nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataIC50:  330nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataIC50:  330nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent