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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 1' and Ligand = 'BDBM322174'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322174
PNG
(N-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)phe...)
Show SMILES O=C(Nc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N1CCOCC1
Show InChI InChI=1S/C22H21N7O2/c30-22(29-8-10-31-11-9-29)26-17-3-1-2-15(12-17)21-23-7-6-20(27-21)25-18-4-5-19-16(13-18)14-24-28-19/h1-7,12-14H,8-11H2,(H,24,28)(H,26,30)(H,23,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair