BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Ribosomal protein S6 kinase (P70S6K)' and Ligand = 'BDBM224417'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM224417
PNG
(US10080750, Compound 94 | US9321760, 94 | US966233...)
Show SMILES Nc1ncnc(N2CCN(CC2)[C@@H](CN2CCC2)c2ccc3OCCOc3c2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C27H31FN6O2/c28-21-5-2-19(3-6-21)25-26(29)30-18-31-27(25)34-12-10-33(11-13-34)22(17-32-8-1-9-32)20-4-7-23-24(16-20)36-15-14-35-23/h2-7,16,18,22H,1,8-15,17H2,(H2,29,30,31)/t22-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US9662330 (2017)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM224417
PNG
(US10080750, Compound 94 | US9321760, 94 | US966233...)
Show SMILES Nc1ncnc(N2CCN(CC2)[C@@H](CN2CCC2)c2ccc3OCCOc3c2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C27H31FN6O2/c28-21-5-2-19(3-6-21)25-26(29)30-18-31-27(25)34-12-10-33(11-13-34)22(17-32-8-1-9-32)20-4-7-23-24(16-20)36-15-14-35-23/h2-7,16,18,22H,1,8-15,17H2,(H2,29,30,31)/t22-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60E+3n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US9321760 (2016)


BindingDB Entry DOI: 10.7270/Q2R78D2R
More data for this
Ligand-Target Pair