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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Chk1' and Ligand = 'BDBM323107'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM323107
PNG
(US9630931, Example 5)
Show SMILES COc1cc(CCNC[C@H]2CCCNC2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1/C21H26ClN7O2/c1-31-19-7-15(4-6-25-11-14-3-2-5-24-10-14)17(22)8-18(19)28-21(30)29-20-13-26-16(9-23)12-27-20/h7-8,12-14,24-25H,2-6,10-11H2,1H3,(H2,27,28,29,30)/t14-/s2
PDB
MMDB

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UniProtKB/SwissProt

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GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 0.0600n/an/an/an/an/an/a



SENTINEL ONCOLOGY LIMITED

US Patent


Assay Description
Reaction Buffer:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOReq...


US Patent US9630931 (2017)


Article DOI: 10.1021/jm9000488
BindingDB Entry DOI: 10.7270/Q29C70J1
More data for this
Ligand-Target Pair