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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-3' and Ligand = 'BDBM352143'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352143
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)N1CC(C)(O)C1
Show InChI InChI=1S/C27H31F3N6O/c1-16-7-17(31)13-35(12-16)24-5-6-32-11-23(24)33-10-18-3-4-20(28)26(34-18)25-21(29)8-19(9-22(25)30)36-14-27(2,37)15-36/h3-6,8-9,11,16-17,33,37H,7,10,12-15,31H2,1-2H3/t16-,17+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair