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Found 7 Enz. Inhib. hit(s) with Target = 'Serine-protein kinase ATM' and Ligand = 'BDBM50145038'
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50145038(CHEMBL2143829)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length Flag-tagged ATM (unknown origin) using GST-p53(1 to 101 residues) as substrates incubated for 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50145038(CHEMBL2143829)
Affinity DataIC50:  20nMAssay Description:Inhibition of flag-tagged ATM (unknown origin) using p53 as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50145038(CHEMBL2143829)
Affinity DataIC50:  21nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50145038(CHEMBL2143829)
Affinity DataIC50:  370nMAssay Description:Competitive inhibition of ATM (unknown origin) measured by ATP-competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50145038(CHEMBL2143829)
Affinity DataIC50:  400nMAssay Description:Inhibition of ATM kinase in human MCF7 cells after 1 hr by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50145038(CHEMBL2143829)
Affinity DataIC50:  480nMAssay Description:Inhibition of ATM in human MCF7 cells assessed as reduction in KAP1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50145038(CHEMBL2143829)
Affinity DataIC50:  3.42E+3nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed