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Found 5 Enz. Inhib. hit(s) with Target = 'Sodium/hydrogen exchanger 3' and Ligand = 'BDBM381826'
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
Ardelyx

Curated by ChEMBL
LigandPNGBDBM381826(US10272079, Compound 003)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibito...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/hydrogen exchanger 3(Rattus norvegicus)
Ardelyx

Curated by ChEMBL
LigandPNGBDBM381826(US10272079, Compound 003)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/hydrogen exchanger 3(Rattus norvegicus)
Ardelyx

Curated by ChEMBL
LigandPNGBDBM381826(US10272079, Compound 003)
Affinity DataIC50:  2.51nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
Ardelyx

Curated by ChEMBL
LigandPNGBDBM381826(US10272079, Compound 003)
Affinity DataIC50:  7.94nMAssay Description:The ability of compounds to inhibit Rat NHE3-mediated Na+-dependent H+ antiport after application and washout was measured using a modification of th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
Ardelyx

Curated by ChEMBL
LigandPNGBDBM381826(US10272079, Compound 003)
Affinity DataIC50:  10nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent