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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 10 subunit alpha' and Ligand = 'BDBM181218'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181218
PNG
(US9139529, 61 | US9783501, Compound 61)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18FN3O5S/c1-31-21-12-15(24)9-10-20(21)32-23-18(11-14-5-2-3-8-19(14)27-23)22(28)26-16-6-4-7-17(13-16)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 11n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair