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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 9 subunit alpha' and Ligand = 'BDBM145327'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145327
PNG
(US8952169, 106 | US9771376, Example 106)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@@H](CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H18ClF4NO4S/c1-27(24,25)22-15(23)11-6-12(17)14(7-13(11)18)26-8-9-2-4-10(5-3-9)16(19,20)21/h6-7,9-10H,2-5,8H2,1H3,(H,22,23)/t9-,10-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 84.7n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145327
PNG
(US8952169, 106 | US9771376, Example 106)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@@H](CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H18ClF4NO4S/c1-27(24,25)22-15(23)11-6-12(17)14(7-13(11)18)26-8-9-2-4-10(5-3-9)16(19,20)21/h6-7,9-10H,2-5,8H2,1H3,(H,22,23)/t9-,10-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 84.7n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145327
PNG
(US8952169, 106 | US9771376, Example 106)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@@H](CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H18ClF4NO4S/c1-27(24,25)22-15(23)11-6-12(17)14(7-13(11)18)26-8-9-2-4-10(5-3-9)16(19,20)21/h6-7,9-10H,2-5,8H2,1H3,(H,22,23)/t9-,10-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 158n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair