Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 9 subunit alpha' and Ligand = 'BDBM231342'
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM231342(US9346798, 89)
Affinity DataIC50:  28.5nMAssay Description:HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM231342(US9346798, 89)
Affinity DataIC50:  460nMAssay Description:Inhibition of human NaV1.7 expressed in HEK293 cells at holding potential of -125 mV with test potentials to -10 mV by whole cell voltage clamp metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM231342(US9346798, 89)
Affinity DataIC50:  464nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Amgen

Curated by ChEMBL
LigandPNGBDBM231342(US9346798, 89)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of rat NaV1.7 by cell based whole cell voltage clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed