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Found 3 Enz. Inhib. hit(s) with Target = 'Stromelysin-1' and Ligand = 'BDBM12075'
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataKi:  4.40nM ΔG°:  -47.7kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  12nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed