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Found 4 Enz. Inhib. hit(s) with Target = 'TGF-beta receptor type-1' and Ligand = 'BDBM172458'
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172458(US9090625, 13 | US9260450, 13 | US9938289, 13)
Affinity DataIC50:  18.9nMAssay Description:Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172458(US9090625, 13 | US9260450, 13 | US9938289, 13)
Affinity DataIC50:  18.9nMAssay Description:ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172458(US9090625, 13 | US9260450, 13 | US9938289, 13)
Affinity DataIC50:  18.9nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172458(US9090625, 13 | US9260450, 13 | US9938289, 13)
Affinity DataIC50:  57.5nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair
In DepthDetails US Patent