BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Thyrotropin-releasing hormone receptor 2' and Ligand = 'BDBM50196450'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thyrotropin-releasing hormone receptor 2


(Rattus norvegicus)
BDBM50196450
PNG
((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Show SMILES CC(C)c1ncc(C[C@H](NC(=O)[C@@H]2CCC(=O)C2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1
Show InChI InChI=1S/C20H29N5O4/c1-11(2)18-22-10-13(23-18)9-15(24-19(28)12-5-6-14(26)8-12)20(29)25-7-3-4-16(25)17(21)27/h10-12,15-16H,3-9H2,1-2H3,(H2,21,27)(H,22,23)(H,24,28)/t12-,15+,16+/m1/s1
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]N(1)-Me-His-TRH from TRHR2


Citation and Details
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor 2


(Rattus norvegicus)
BDBM50196450
PNG
((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Show SMILES CC(C)c1ncc(C[C@H](NC(=O)[C@@H]2CCC(=O)C2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1
Show InChI InChI=1S/C20H29N5O4/c1-11(2)18-22-10-13(23-18)9-15(24-19(28)12-5-6-14(26)8-12)20(29)25-7-3-4-16(25)17(21)27/h10-12,15-16H,3-9H2,1-2H3,(H2,21,27)(H,22,23)(H,24,28)/t12-,15+,16+/m1/s1
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activity


Citation and Details
More data for this
Ligand-Target Pair