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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tissue-type plasminogen activator' and Ligand = 'BDBM50142150'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50142150
PNG
(1-{4-[4-Chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-...)
Show SMILES C[N+]1(Cc2ccc(cc2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)CCCC1
Show InChI InChI=1S/C25H24Cl2N4O2/c1-31(12-2-3-13-31)16-17-4-6-18(7-5-17)24(32)29-22-10-8-19(26)14-21(22)25(33)30-23-11-9-20(27)15-28-23/h4-11,14-15H,2-3,12-13,16H2,1H3,(H-,28,29,30,32,33)/p+1
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Article
PubMed
n/an/a>1.10E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against tissue type plasminogen activator.


Bioorg Med Chem Lett 14: 989-93 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.080
BindingDB Entry DOI: 10.7270/Q2X34WXD
More data for this
Ligand-Target Pair