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Found 1 hit Enz. Inhib. hit(s) with Target = 'Topoisomerase II alpha (HuTopoIIα)' and Ligand = 'BDBM50295259'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Topoisomerase II alpha (HuTopoIIα)


(Homo sapiens (Human))
BDBM50295259
PNG
(CHEMBL549357 | N2-(benzo[d]thiazol-6-yl)-N6-cycloh...)
Show SMILES C1CCCC(CC1)Nc1nc(Nc2ccc3ncsc3c2)nc2nc[nH]c12
Show InChI InChI=1S/C19H21N7S/c1-2-4-6-12(5-3-1)23-18-16-17(21-10-20-16)25-19(26-18)24-13-7-8-14-15(9-13)27-11-22-14/h7-12H,1-6H2,(H3,20,21,23,24,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.40E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of ATPase activity of human topoisomerase 2 alpha


Bioorg Med Chem Lett 19: 4014-7 (2009)

More data for this
Ligand-Target Pair