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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential M8 protein (TRPM8)' and Ligand = 'BDBM241605'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241605
PNG
(US9409915, 94 | US9718820, Compound 94)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(cnc2[nH]1)-c1ccccc1OC(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C20H18ClF3N6O/c1-19(2,3)15-13(21)14(30(4)29-15)16-27-17-18(28-16)26-11(9-25-17)10-7-5-6-8-12(10)31-20(22,23)24/h5-9H,1-4H3,(H,25,26,27,28)
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22.5n/an/an/an/an/a25



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...


US Patent US9718820 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241605
PNG
(US9409915, 94 | US9718820, Compound 94)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(cnc2[nH]1)-c1ccccc1OC(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C20H18ClF3N6O/c1-19(2,3)15-13(21)14(30(4)29-15)16-27-17-18(28-16)26-11(9-25-17)10-7-5-6-8-12(10)31-20(22,23)24/h5-9H,1-4H3,(H,25,26,27,28)
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22.5n/an/an/an/an/a37



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


US Patent US9409915 (2016)


BindingDB Entry DOI: 10.7270/Q23J3BVJ
More data for this
Ligand-Target Pair