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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential M8 protein (TRPM8)' and Ligand = 'BDBM241640'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241640
PNG
(US9409915, 24 | US9718820, Compound 24)
Show SMILES CN1CCN(CC1)c1nc(cc2nc([nH]c12)-c1c(C#N)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H29F3N8/c1-26(2,3)23-17(15-31)22(37(5)35-23)24-32-20-14-19(16-8-6-7-9-18(16)27(28,29)30)33-25(21(20)34-24)38-12-10-36(4)11-13-38/h6-9,14H,10-13H2,1-5H3,(H,32,34)
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.40n/an/an/an/an/a25



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...


US Patent US9718820 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241640
PNG
(US9409915, 24 | US9718820, Compound 24)
Show SMILES CN1CCN(CC1)c1nc(cc2nc([nH]c12)-c1c(C#N)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H29F3N8/c1-26(2,3)23-17(15-31)22(37(5)35-23)24-32-20-14-19(16-8-6-7-9-18(16)27(28,29)30)33-25(21(20)34-24)38-12-10-36(4)11-13-38/h6-9,14H,10-13H2,1-5H3,(H,32,34)
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.40n/an/an/an/an/a37



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


US Patent US9409915 (2016)


BindingDB Entry DOI: 10.7270/Q23J3BVJ
More data for this
Ligand-Target Pair