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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 1' and Ligand = 'BDBM50372585'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50372585
PNG
(CHEMBL404165)
Show SMILES OC1CCc2cccc(Nc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2C1
Show InChI InChI=1S/C21H18F3N3O/c22-21(23,24)15-7-4-14(5-8-15)19-11-20(26-12-25-19)27-18-3-1-2-13-6-9-16(28)10-17(13)18/h1-5,7-8,11-12,16,28H,6,9-10H2,(H,25,26,27)
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 0.580n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization


Bioorg Med Chem Lett 18: 1830-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.022
BindingDB Entry DOI: 10.7270/Q2FB53SJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50372585
PNG
(CHEMBL404165)
Show SMILES OC1CCc2cccc(Nc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2C1
Show InChI InChI=1S/C21H18F3N3O/c22-21(23,24)15-7-4-14(5-8-15)19-11-20(26-12-25-19)27-18-3-1-2-13-6-9-16(28)10-17(13)18/h1-5,7-8,11-12,16,28H,6,9-10H2,(H,25,26,27)
PDB
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.620n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization


Bioorg Med Chem Lett 18: 1830-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.022
BindingDB Entry DOI: 10.7270/Q2FB53SJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50372585
PNG
(CHEMBL404165)
Show SMILES OC1CCc2cccc(Nc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2C1
Show InChI InChI=1S/C21H18F3N3O/c22-21(23,24)15-7-4-14(5-8-15)19-11-20(26-12-25-19)27-18-3-1-2-13-6-9-16(28)10-17(13)18/h1-5,7-8,11-12,16,28H,6,9-10H2,(H,25,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.650n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization


Bioorg Med Chem Lett 18: 1830-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.022
BindingDB Entry DOI: 10.7270/Q2FB53SJ
More data for this
Ligand-Target Pair