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Found 4 Enz. Inhib. hit(s) with Target = 'Transthyretin' and Ligand = 'BDBM138358'
TargetTransthyretin(Homo sapiens (Human))
The Board Of Trustees Of The Leland Stanford Junior University

US Patent
LigandPNGBDBM138358(US10278929, Compound 7 | US11337935, Compound 7 | ...)
Affinity DataIC50:  296nMAssay Description:The FP assay was then adapted for HTS and used to screen ~120,000 small molecule library for compounds that displaced probe 5 from the T4 binding of ...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
The Board Of Trustees Of The Leland Stanford Junior University

US Patent
LigandPNGBDBM138358(US10278929, Compound 7 | US11337935, Compound 7 | ...)
Affinity DataIC50:  296nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
The Board Of Trustees Of The Leland Stanford Junior University

US Patent
LigandPNGBDBM138358(US10278929, Compound 7 | US11337935, Compound 7 | ...)
Affinity DataIC50:  296nMAssay Description:The FP assay was then adapted for HTS and used to screen a ˜120,000 member small molecule library for compounds that displaced the FP probe from the ...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
The Board Of Trustees Of The Leland Stanford Junior University

US Patent
LigandPNGBDBM138358(US10278929, Compound 7 | US11337935, Compound 7 | ...)
Affinity DataKd:  320nMAssay Description:Dissociation Constants (Kd) associated with the binding of ligands to TTR are expressed in nM. Thermodynamic Binding Parameters associated with ligan...More data for this Ligand-Target Pair