Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM111945'
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM111945(US8618107, 113)
Affinity DataIC50:  4nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of BCR-induced CD69 expression on B cells prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM111945(US8618107, 113)
Affinity DataIC50:  5nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM111945(US8618107, 113)
Affinity DataIC50:  45nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of BCR-induced CD69 expression on B cells prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Mus musculus)
Genentech

Curated by ChEMBL
LigandPNGBDBM111945(US8618107, 113)
Affinity DataIC50:  107nMAssay Description:Inhibition of BTK in goat F(ab')2anti-mouse IgM-stimulated Balb/c mouse splenocyte B cells assessed as suppression of BCR-mediated CD86 induction pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed