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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM264155'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264155
PNG
(US9714234, 30)
Show SMILES CC(=O)NCc1ccc2c(c1)[nH]c1c(ccc(-c3cccc(c3C)-n3c(=O)cc4c(F)cccn4c3=O)c21)C(N)=O
Show InChI InChI=1S/C31H24FN5O4/c1-16-19(5-3-7-25(16)37-27(39)14-26-23(32)6-4-12-36(26)31(37)41)20-10-11-22(30(33)40)29-28(20)21-9-8-18(13-24(21)35-29)15-34-17(2)38/h3-14,35H,15H2,1-2H3,(H2,33,40)(H,34,38)
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, INVITROGEN Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9714234 (2017)

More data for this
Ligand-Target Pair