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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM264158'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM264158
PNG
(US9714234, 33)
Show SMILES Cc1c(cccc1-n1c(=O)n(C)c2c(F)cccc2c1=O)-c1ccc(C(N)=O)c2[nH]c3c(F)c(ccc3c12)C(C)(C)O
Show InChI InChI=1S/C32H26F2N4O4/c1-15-16(7-6-10-23(15)38-30(40)20-8-5-9-22(33)28(20)37(4)31(38)41)17-11-12-19(29(35)39)26-24(17)18-13-14-21(32(2,3)42)25(34)27(18)36-26/h5-14,36,42H,1-4H3,(H2,35,39)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, INVITROGEN Corporation), fluoresceinated peptide (1.5 μM), A...


US Patent US9714234 (2017)

More data for this
Ligand-Target Pair