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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM317620'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM317620
PNG
(US9624201, Compound 9 | {5-Amino-1- [4-(2,3- diflu...)
Show SMILES Cc1cc(Oc2cccc(F)c2F)ccc1-n1ncc(C(=O)c2cc3c(Cc4ccccc4)cccc3[nH]2)c1N
Show InChI InChI=1S/C32H24F2N4O2/c1-19-15-22(40-29-12-6-10-25(33)30(29)34)13-14-28(19)38-32(35)24(18-36-38)31(39)27-17-23-21(9-5-11-26(23)37-27)16-20-7-3-2-4-8-20/h2-15,17-18,37H,16,35H2,1H3
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 33.1n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.; CHUGAI PHARMACEUTICAL CO.

US Patent


Assay Description
The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of Btk, biotinylated SH2 peptide substrate (Src...


US Patent US9624201 (2017)

More data for this
Ligand-Target Pair