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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM348558'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348558
PNG
(US9790229, Compound 281)
Show SMILES C[C@H]1CCN(C[C@@H]1N1CCCC(Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc(N)c1F
Show InChI InChI=1S/C21H25Cl2FN6O/c1-12-4-6-29(20-18(24)19(25)26-11-27-20)10-17(12)30-5-2-3-16(21(30)31)28-15-8-13(22)7-14(23)9-15/h7-9,11-12,16-17,28H,2-6,10H2,1H3,(H2,25,26,27)/t12-,16?,17-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair