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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM362369'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM362369
PNG
(4-{7-amino-3-[(3R)-1- (1,2,5-oxadiazol-3- ylcarbon...)
Show SMILES Nc1nccc2c(nn(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CCCN(C1)C(=O)c1cnon1
Show InChI InChI=1/C27H22F3N9O3/c28-27(29,30)17-7-9-32-21(12-17)35-25(40)15-3-5-18(6-4-15)39-23-19(8-10-33-24(23)31)22(36-39)16-2-1-11-38(14-16)26(41)20-13-34-42-37-20/h3-10,12-13,16H,1-2,11,14H2,(H2,31,33)(H,32,35,40)/t16-/s2
PDB
MMDB

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Article
US Patent
n/an/a 4.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...


US Patent US9834554 (2017)


Article DOI: 10.1016/j.bmcl.2005.12.095
More data for this
Ligand-Target Pair