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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM377852'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377852
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)C(\F)=C\CO
Show InChI InChI=1/C25H24F3N5O4/c26-15-5-8-20(19(28)12-15)37-17-6-3-14(4-7-17)22-21(24(30)35)23(29)33(31-22)16-2-1-10-32(13-16)25(36)18(27)9-11-34/h3-9,12,16,34H,1-2,10-11,13,29H2,(H2,30,35)/b18-9-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 48n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair