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Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ITK/TSK' and Ligand = 'BDBM50257653'
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257653(CHEMBL492757 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  100nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257653(CHEMBL492757 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of ITK (unknown origin) in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257653(CHEMBL492757 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50: >5.00E+3nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed